DNA sequence from the unzipping force? : one mutation problem
نویسندگان
چکیده
The possibility of detecting mutations in a DNA from force measurements (as a first step towards sequence analysis) is discussed theoretically based on exact calculations. The force signal is associated with the domain wall separating the zipped from the unzipped regions. We propose a comparison method (“differential force microscope”) to detect mutations. Two lattice models are treated as specific examples. 87.14Gg, 87.80Fe, 05.20Gg
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تاریخ انتشار 2001